• importx posted an update 1 month, 1 week ago

    HSP and immunity1. HSP60 and clinical immunityHSP60 is one of the most closely related heat shock proteins in the immune system. But in the 1990s and before, the research on HSP60 mainly focused on the clinical. Hsp60 is involved in the occurrence and development of many clinical diseases, such as autoimmune diseases, chronic inflammatory diseases, endocrine system diseases, myocarditis, arteriosclerosis and parasitic infectious diseases.In 1990, some scientists conducted experiments on HSP60. The results showed that: ① HSP60 from pathogenic microorganisms may be used as an exogenous antigen to stimulate the innate immune response of the body, and may also be used as an important factor to infect the body or cause the pathological immune response; ② the antibodies produced in the anti-infection immune response may cause the cross reaction of anti-hsp60 and lead to autoimmune diseases; ③ production of heat shock protein vaccines. Different scientists have found the same phenomenon in different diseases. The occurrence of these diseases is largely related to the anti HSP60 antibody produced by pathogens after infecting the body, and affects the development and prognosis of these diseases.2. HSP60 and basic immunityIn the aspect of basic immunity, the research on HSP60 is late, but it has made rapid progress. There are many related literature reports. Many studies have suggested that HSP60 can activate APC, induce the release of many cytokines and stimulate innate immune responses. HSP60 is also helpful for the clearance of necrotic cells. Endogenous HSP60, which is released by necrosis rather than apoptosis caused by various factors, can be used as a dangerous signal to stimulate the immune system, activate immune cells, and finally lead to the clearance of necrotic cells.

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